Glutamate receptors in the hypothalamic paraventricular nucleus contribute to insulin-induced sympathoexcitation
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چکیده
منابع مشابه
Glutamate receptors in the hypothalamic paraventricular
22 The sympathoexcitatory response to insulin is mediated by neurons in the arcuate 23 nucleus (ARC) and hypothalamic paraventricular nucleus (PVH). Previous studies have 24 reported that stimulation of ARC neurons increases sympathetic nerve activity (SNA) 25 and arterial blood pressure (ABP) through glutamate receptor activation in the PVH. 26 Therefore, the purpose of the present study was t...
متن کاملSympathetic response to insulin is mediated by melanocortin 3/4 receptors in the hypothalamic paraventricular nucleus.
Hyperinsulinemia increases sympathetic nerve activity and contributes to cardiovascular dysfunction in obesity and diabetes. Neurons of the hypothalamic paraventricular nucleus (PVN) regulate sympathetic nerve activity through mono- and poly-synaptic connections to preganglionic neurons in the spinal cord. The purpose of the present study was to determine whether PVN neurons mediate the sympath...
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Hypertension (HTN) resulting from subcutaneous infusion of ANG II and dietary high salt (HS) intake involves sympathoexcitation. Recently, we reported reduced small-conductance Ca(2+)-activated K(+) (SK) current and increased excitability of presympathetic neurons in the paraventricular nucleus (PVN) in ANG II-salt HTN. Here, we hypothesized that ANG II-salt HTN would be accompanied by altered ...
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The hypothalamic paraventricular nucleus (PVN) is important for maintenance of sympathetic nerve activity (SNA) and cardiovascular function. PVN-mediated increases of SNA often involve the excitatory amino acid L-glutamate (L-glu), whose actions can be positively and negatively modulated by a variety of factors, including reactive oxygen species. Here, we determined modulatory effects of the hi...
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Introduction: It has been shown that administration of WIN55,212-2, a cannabinoid receptor agonist, into the basolateral amygdala (BLA), dose-dependently increases the thermal latency to withdrawal in the tail-.ick test and decreases pain related behaviors in both phases of the formalin test. Recent human and animal imaging data suggest that the nucleus accumbens (NAc) is an important neural su...
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ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2015
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.00764.2014